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KMID : 1161520150190060385
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Animal Cells and Systems
2015 Volume.19 No. 6 p.385 ~ p.392
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BAF53 is required for mitotic progression
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Lee Ah-Young
Lyu Soo-Kyung
Kwon Hyock-Man
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Abstract
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The progression of the cell cycle into the G2 and M phases is orchestrated by the induction of G2/M-specific genes. Many of the G2/M-specific genes play roles in the timely entry and termination of mitosis and the faithful segregation of mitotic chromosomes. In this study, we found that BAF53 knockdown led to a cell cycle delay in the G2 phase, a mis-segregation of mitotic chromosomes, and an escape from the mitotic arrest induced by the spindle assembly checkpoint. The induction of cyclin B1, CENP-F, Aurora A, and Aurora B was either delayed or suppressed in BAF53-depleted cells. These data suggest that the dysregulation of G2/M-specific gene expression could be responsible for the pleiotropic mitotic defects observed in BAF53-depleted cells.
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KEYWORD
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BAF53, CENP-F, G2/M-specific genes, mitosis
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